Periprosthetic joint infections in femoral neck fracture patients treated with hemiarthroplasty – should we use antibiotic-loaded bone cement?

BACKGROUND Hemiarthroplasty is the most common treatment in elderly patients with displaced intra-capsular femoral neck fracture (FNF). Prosthetic joint infection (PJI) is one of the most feared and frequent complications post-surgery because of the frail health status of these patients and the need for fast track surgery. Therefore, priorities should lie in effective preventive strategies to mitigate this burden. AIM To determine how much the implementation of the routine use of antibiotic-loaded bone cement (ALBC) as a relatively easy-to-apply amendment to the surgical practice reduces the infection rate in our hemiarthroplasty cohort. METHODS We retrospectively assessed all demographic, health status and treatment-related data of our FNF patients undergoing cemented hemiarthroplasty in the period from 2011 to 2017; 241 patients were further analyzed after exclusion of patients with cancer-related sequelae and those who died before the end of the 1-year observation period. The PJI rate as diagnosed on basis of the Musculoskeletal Infection Society (MSIS) criteria 2011 was determined for each included patient and compared in function of the bone cement used for hip stem fixation. Patients were split into a group receiving a plain bone cement in the period from January 2011 to June 2013 (non-ALBC group) and into a group receiving an ALBC in the period July 2013 to December 2017 (ALBC group). Data analysis was performed with statistical software. We further calculated the cost-efficacy of the implementation of routine use of ALBC in the second group balancing the in-hospital infection related treatment costs with the extra costs of use of ALBC. RESULTS In total 241 FNF patients who received cemented hemiarthroplasty in the period from January 2011 to January 2017 were eligible for inclusion in this retrospective study. There were 8 PJI cases identified in the ALBC group among n = 94 patients, whereas 28 PJI cases were observed in the non-ALBC group among n = 147 patients. The statistical analysis showed an infection risk reduction of 55.3% (in particular due to the avoidance of chronic delayed infections) in the ALBC group (95%CI: 6.2%-78.7%; P = 0.0025). The cost-evaluation analysis demonstrated a considerable cost saving of 3.500 € per patient, related to the implementation of routine use of ALBC in this group. CONCLUSION Use of ALBC is a potent infection preventive factor in FNF patients receiving cemented hemiarthroplasties. It was further found to be highly cost-effective.post-print314 K

Primer registro de Litomosoides pardinasi (Nematoda: Onchocercidae) en roedores nativos y exóticos de Chile

Litomosoides pardinasi es registrada por primera vez en roedores nativos y exóticos de Chile. La especie Litomosoides pardinasi, parásita de Phyllotis xanthopygus y Oligoryzomys longicaudatus en la Patagonia Argentina, fue encontrada en Chile parasitando la cavidad torácica y abdominal de O. longicaudatus (prevalencia (P)= 18.9%, intensidad media (MI)= 57.3) y de Phyllotis darwini (P= 4.2%, MI= 10), y la cavidad abdominal del roedor exótico Rattus rattus (P= 1.24%; MI= 22.5). La P total en roedores nativos de Chile fue significativamente menor que la P de Argentina, en tanto la MI total fue significativamente mayor. La P y MI de L. pardinasi en O. longicaudatus de Chile y Argentina no mostraron diferencias significativas; la P en P. darwini de Chile fue significativamente menor que la de P. xanthopygus de Argentina y que la de O. longicaudatus de Chile. Considerando la distribución de las especies de Litomosoides entre los sigmodontinos, estos resultados apoyan la hipótesis que L. pardinasi está bien establecida en O. longicaudatus y que posiblemente haya sido recientemente adquirida por P. darwini y R. rattus. Así, L. pardinasi colonizó primero a la Tribu Oryzomyini y posteriormente por un fenómeno de cambio de hospedero a la Tribu Phyllotini y a R. rattus.We report the first record of Litomosoides pardinasi in native and exotic rodents from Chile. Litomosoides pardinasi, described in the Argentine Patagonia parasitizing Phyllotis xanthopygus and Oligoryzomys longicaudatus, was found in Chile parasitizing the peritoneal and thoracic cavities of O. longicaudatus (prevalence (P)= 18.9%, mean intensity (MI)= 57.3) and Phyllotis darwini (P= 4.2%, MI= 10), and in the peritoneal cavity of Rattus rattus (P= 1.24%; MI= 22.5). Total P in native rodents from Chile was significantly lower than in Argentina, while the total MI was higher. Prevalence and MI of L. pardinasi in O. longicaudatus from Chile and Argentina showed non-significant differences; prevalence in P. darwini from Chile was significantly lower than in P. xanthopygus from Argentina and than in Chilean O. longicaudatus. Our results, together with those from Argentina, support the hypothesis that L. pardinasi is well established in O. longicaudatus, but seems to be recently acquired by P. darwini and the exotic R. rattus. Considering the known host distribution of Litomosoides species among the sigmodontines, our results also support the hypothesis that L. pardinasi first colonized the Oryzomyini tribe and later, by different phenomena of host-switching, colonized the Phyllotini tribe and the exotic R. rattus.Fil: Landaeta Aqueveque, Carlos. Universidad de Concepción; ChileFil: Notarnicola, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Estudios Parasitológicos y de Vectores. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Estudios Parasitológicos y de Vectores; ArgentinaFil: Correa, Juana P.. Universidad de Chile; ChileFil: Yánez Mesa, Andrea. Universidad de Chile; ChileFil: Henriquez, AnaLía. Universidad Santo Tomás; ChileFil: Cattan, Pedro E.. Universidad de Chile; ChileFil: Botto Mahan, Carezza. Universidad de Chile; ChileFil: Torres Pérez, Fernando. Pontificia Universidad Catolica de Valparaiso; Chil

An International Consensus List of Potentially Clinically Significant Drug-Drug Interactions in Older People.

Objectives We aimed to establish an explicit list of potentially clinically significant drug-drug interactions (DDIs) in people aged ≥65 years. Design A preliminary list of potentially clinically significant DDIs was compiled, based on 154 DDIs identified from literature review. Subsequently, a 2-round online Delphi survey was undertaken with a multidisciplinary expert panel. A consensus meeting and a final round were conducted to validate the final DDI list and the scope of information provided. Setting and Participants Twenty nine experts, including geriatricians and clinical pharmacists from 8 European countries. Measures For each DDI, in the first 2 rounds, experts were asked to score the severity of potential harm on a 5-point Likert-type scale. DDIs were directly included on the final list if the median score was 4 (major) or 5 (catastrophic). DDIs with a median score of 3 (moderate) were discussed at a consensus meeting and included if ≥75% of participants voted for inclusion in the final round. Results Consensus was achieved on 66 potentially clinically significant DDIs (28 had a median score of 4/5 and 48 of 3 in the Delphi survey). Most concerned cardiovascular, antithrombotic, and central nervous system drugs. The final list includes information on the mechanism of interaction, harm, and management. Treatment modification is recommended for three-quarters of DDIs. Conclusion and Implications We validated a list of potentially clinically significant DDIs in older people, which can be used in clinical practice and education to support identification and management of DDIs or to assess prevalence in epidemiologic and intervention studies.pre-print896 K

Primer registro de Litomosoides pardinasi (Nematoda: Onchocercidae) en roedores nativos y exóticos de Chile

We report the first record of Litomosoides pardinasi in native and exotic rodents from Chile. Litomosoides pardinasi, described in the Argentine Patagonia parasitizing Phyllotis xanthopygus and Oligoryzomys longicaudatus, was found in Chile parasitizing the peritoneal and thoracic cavities of O. longicaudatus (prevalence (P)= 18.9%, mean intensity (MI)= 57.3) and Phyllotis darwini (P= 4.2%, MI= 10), and in the peritoneal cavity of Rattus rattus (P= 1.24%; MI= 22.5). Total P in native rodents from Chile was significantly lower than in Argentina, while the total MI was higher. Prevalence and MI of L. pardinasi in O. longicaudatus from Chile and Argentina showed non-significant differences; prevalence in P. darwini from Chile was significantly lower than in P. xanthopygus from Argentina and than in Chilean O. longicaudatus. Our results, together with those from Argentina, support the hypothesis that L. pardinasi is well established in O. longicaudatus, but seems to be recently acquired by P. darwini and the exotic R. rattus. Considering the known host distribution of Litomosoides species among the sigmodontines, our results also support the hypothesis that L. pardinasi first colonized the Oryzomyini tribe and later, by different phenomena of host-switching, colonized the Phyllotini tribe and the exotic R. rattus.Litomosoides pardinasi es registrada por primera vez en roedores nativos y exóticos de Chile. La especie Litomosoides pardinasi, parásita de Phyllotis xanthopygus y Oligoryzomys longicaudatus en la Patagonia Argentina, fue encontrada en Chile parasitando la cavidad torácica y abdominal de O. longicaudatus (prevalencia (P)= 18.9%, intensidad media (MI)= 57.3) y de Phyllotis darwini (P= 4.2%, MI= 10), y la cavidad abdominal del roedor exótico Rattus rattus (P= 1.24%; MI= 22.5). La P total en roedores nativos de Chile fue significativamente menor que la P de Argentina, en tanto la MI total fue significativamente mayor. La P y MI de L. pardinasi en O. longicaudatus de Chile y Argentina no mostraron diferencias significativas; la P en P. darwini de Chile fue significativamente menor que la de P. xanthopygus de Argentina y que la de O. longicaudatus de Chile. Considerando la distribución de las especies de Litomosoides entre los sigmodontinos, estos resultados apoyan la hipótesis que L. pardinasi está bien establecida en O. longicaudatus y que posiblemente haya sido recientemente adquirida por P. darwini y R. rattus. Así, L. pardinasi colonizó primero a la Tribu Oryzomyini y posteriormente por un fenómeno de cambio de hospedero a la Tribu Phyllotini y a R. rattus.Facultad de Ciencias Naturales y Muse

Dataset of occurrence and incidence of pine processionary moth in Andalusia, south Spain

This dataset provides information about infestation caused by the pine processionary moth (Thaumetopoea pityocampa ([Denis & Schiffermüller], 1775)) in pure or mixed pine woodlands and plantations in Andalusia. It represents a long-term series (1993–2015) containing 81,908 records that describe the occurrence and incidence of this species. Data were collected within a monitoring programme known as COPLAS, developed by the Regional Ministry of Environment and Territorial Planning of the Andalusian Regional Government within the frame of the Plan de Lucha Integrada contra la Procesionaria del Pino (Plan for Integrated Control Against the Pine Processionary Moth). In particular, this dataset includes 4,386 monitoring stands which, together with the campaign year, define the dataset events in Darwin Core Archive. Events are related with occurrence data which show if the species is present or absent. In turn, the event data have a measurement associated: degree of infestation.This work has been carried out under the conceptual framework and cooperative spirit of the Sierra Nevada Global Change Observatory and it was supported by the H2020 project “ECOPOTENTIAL: Improving future ecosystem benefits through earth observations” (http://www.ecopotential-project.eu/), which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 641762. Thanks are due to the projects that fund the research with the following contracts: A. J. Pérez-Luque has a contract within the project LIFE-ADAPTAMED (LIFE14 CCA/ES/000612): “Protection of key ecosystem services by adaptive management of Climate Change endangered Mediterranean socioecosystems” and A. Ros Candeira has a contract within the National Youth Guarantee System and the operational programme “Youth Employment” financed by the European Social Fund

Dios Curriculista- un análisis documental sobre la idea de Cuerpo, Formación y Hombre, en los currículos de Educación Física en básica primaria en I. E. Religiosas.

Physical Education curriculum throughout history have been accompanied by different political, economic, social and religious positions, this has led to the fact that, currently, and based on the evaluation exams that are carried out annually (such as the ICFES tests), private and religious educational institutions are the ones that postulate the type of man, body and training that they consider best. In the same way, these educational institutions through their curricula show their different ideological positions, especially about the body. However, the main objective of this research is to interpret the idea of the body that exists in curriculum of the 45 best institutions (according to Sapiens Research), in the city of Medellín, this will be done through the conceptual framework of Pedraza, Z. (2010), Bollnow, O.F. (2005) and Da Silva, T.T. (2001). The methodology has a mixed approach, accompanied by a content analysis as a method and a documentary systematization as a technique. An important finding is that the body for these educational institutions is unilateral, that is, it is understood from the curriculum as a tool, temple or machine, in addition, the distinction between the sexes continues to exist when developing the curriculum in the area of education physical.Los currículos de Educación Física a lo largo de la historia se han visto acompañados de diferentes posturas políticas, económicas, sociales y religiosas, esto ha llevado a que, en la actualidad, y a partir de los exámenes de evaluación realizados anualmente (como las pruebas ICFES) las instituciones educativas (I.E) de carácter privado y religioso sean las que postulen el tipo de hombre, cuerpo y formación que ellos consideran como mejores. Del mismo modo, estas instituciones educativas a través de sus currículos muestran sus diferentes posturas ideológicas, en especial sobre el cuerpo. No obstante, el objetivo principal de esta investigación es interpretar la idea de cuerpo que hay en los currículos de las 45 mejores instituciones de la ciudad de Medellín (Según Sapiens Research), esto se hará mediante el marco conceptual de Pedraza, Z. (2010), Bollnow, O. F. (2005) y Da Silva, T. T. (2001). La metodología tiene un enfoque mixto, acompañada de un análisis de contenido como método y una sistematización documental como técnica. Un hallazgo importante es que el cuerpo para estas instituciones educativas es mono - facético, es decir, se comprende desde el currículo como una herramienta, templo o máquina, además, sigue existiendo la distinción entre sexos a la hora de desarrollar el currículo del área de Educación Física

Colchicine for the primary prevention of cardiovascular events.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the clinical benefit and harms of colchicine as primary prevention of cardiovascular outcomes in the general population.pre-print346 K

The restorative practices in the peace agreement with las Farc : circles of support and accountability

Este artículo propone la utilización de los círculos de apoyo en el marco de implementación del Acuerdo de Paz con las FARC como medida para lograr un efectivo reintegro de los ex combatientes a sus comunidades de origen. Para ello, realiza un breve análisis del contexto en el cual se firmó el Acuerdo para determinar cómo éste refleja el paradigma de justicia restaurativa, y posteriormente, explicar en qué consiste la práctica restaurativa de los círculos de apoyo, su origen y modo de aplicación, y cómo podrían realizarse dentro de las comunidades afectadas por el conflicto para conseguir exitosamente la rehabilitación y reincorporación de los ex combatientes de la guerrilla, generando, además, mayor cohesión social.This article proposes the use of circles of support and accountability within the framework of the implementation of the Peace Agreement with las FARC as means to achieve the effective reinstatement of ex-combatants to their original communities. To do so, it presents a brief analysis of the context in which the Agreement was signed to determine how it reflects the model of restorative justice, and then explains what circles of support and accountability are as a restorative practice, their origin and application, and how they could be executed within the communities that were affected by the armed conflict to successfully achieve the rehabilitation and reincorporation of former members of the guerrilla, which would also generate greater social cohesion